Active research grants

R01 NS071067-06A1 Hadlock (PI)

NIH/NINDS                                                                                                                                                                                         07/01/2010-06/30/2021

Surgical and Rehabilitative Management of Facial Nerve Injury

The scientific goals are through using a rodent model, we propose to employ computer-assisted, patient-specific sensory and motor rehabilitative therapy following facial nerve injury and repair, to measure its benefit and maximize its effect.

2019-2021

Gene Therapy for Peripheral Nerve Repair

Charles H. Hood Foundation Child Health Research Awards

Principal Investigator

To characterize the ability of benign viruses incorporated within bioengineered nerve guidance conduits to deliver gene therapies to enhance neural regeneration

2019-2022

Facial EMG for Neuroprosthetic Device Control in Facial Palsy

AAFPRS Research Scholar Award

Principal Investigator

To characterize relationships between facial surface electromyography signals and facial displacements as a means for control of a neuroprosthetic device for hemifacial palsy.

2019-2020

The Effect of Electrical Stimulation on Schwann Cell States Along Nerve Grafts

Leslie Bernstein Resident Research Grant

Sponsor / Faculty Mentor (PI: Derakshan)

To establish the impact of prolonged electrical stimulation of nerve grafts on Schwann cell phenotypes and neural regeneration.

2019-2020

Quantitative Model of Decompression Surgery for Bell’s Palsy

AAO-HNSF Resident Research Award

Faculty Mentor (PI: Malka)

To establish the impact of facial nerve decompression following various periods of neural compression on long-term facial function outcomes in a rodent model.

2019-2020

Neuronal and Schwann Cell Transcriptional States in Peripheral Nerve Regeneration

Plastic Surgery Foundation / American Society for Peripheral Nerve Combined Pilot Research Grant

Faculty Mentor (PI: Mohan)

To characterize the heterogeneity of Schwann cell transcriptional states during prolonged peripheral nerve denervation and reinnervation.

 

2016-2021

Surgical and Rehabilitative Management of Facial Nerve Injury

NIH - 2R01NS071067 – 06A1

Co-Investigator (PI: Hadlock)

This project seeks to establish in a rodent model a paradigm for hemi-facial reanimation using an implantable neuroprosthetic device (Impact Score: 20, Percentile: 4)

2016-2021

Surgical Photonics and Engineering Laboratory Seed Funding

Berthiaume Family Foundation

PI – Jowett

To support new knowledge discovery and development of novel therapies for complex deformities of the head & neck in the new Surgical Photonics & Engineering Laboratory at Massachusetts Eye and Ear

Past research grants

Function and Form Outcomes in Patients with Facial Paralysis                                4/1/2016-3/31/2018

R21 DE025295-01A1 Hadlock (Co-PI)

NIDCR 1

This project aims to develop a set of clinically useful measurements of the paralyzed face using three dimensional imaging technology

 

Multidisciplinary Laser and Reconstructive Facial Surgery Research             07/1/2013-06/30/2018

Lynch Foundation Hadlock/Tan (PI)  

The scientific goals are to identify molecular markers for a range of vascular anomalies and hemangiomata, to further clinical outcomes studies in facial paralysis and vascular anomalies, and to develop global outreach and training initiatives involving the treatment of facial disfigurement.

2018-2019

Optogenetic Stimulation of the Facial Nerve

AAFPRS Leslie Bernstein Resident Research Grant

Key Personnel – Mentor (PI: Kanumuri)

To characterize whether viral optogene transfection of the facial nerve would allow for optogentic stimulation as a means to achieve functional stimulation of facial movements.

2018-2019

Enhancement of Axonal Penetration through Cross-Facial Nerve Grafts

AAFPRS Leslie Bernstein Resident Research Grant

Key Personnel – Mentor (PI: Mohan)

To study the effects of various surgical strategies on improving axonal regeneration along cross-facial nerve grafts.

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