Research Grants
2019-2021
Gene Therapy for Peripheral Nerve Repair
Charles H. Hood Foundation Child Health Research Awards
Principal Investigator
To characterize the ability of benign viruses incorporated within bioengineered nerve guidance conduits to deliver gene therapies to enhance neural regeneration
2019-2022
Facial EMG for Neuroprosthetic Device Control in Facial Palsy
AAFPRS Research Scholar Award
Principal Investigator
To characterize relationships between facial surface electromyography signals and facial displacements as a means for control of a neuroprosthetic device for hemifacial palsy.
2016-2021
Surgical and Rehabilitative Management of Facial Nerve Injury
NIH - 2R01NS071067 – 06A1
Co-Investigator (PI: Hadlock)
This project seeks to establish in a rodent model a paradigm for hemi-facial reanimation using an implantable neuroprosthetic device (Impact Score: 20, Percentile: 4)
2016-2021
Surgical Photonics and Engineering Laboratory Seed Funding
Berthiaume Family Foundation
PI – Jowett
To support new knowledge discovery and development of novel therapies for complex deformities of the head & neck in the new Surgical Photonics & Engineering Laboratory at Massachusetts Eye and Ear
2021
NIH R-01
Tessa Hadlock, MD, named the site principal investigator
3D Dynamic and Patient-Centered Outcomes of Facial Reanimation Surgery in Patients with Facial Paralysis.
Dr. Hadlock will collaborate with Carroll Ann Trotman, BDS, MA, MS, at Tufts University School of Dental Medicine on using novel 3D models and measures to determine outcomes of mid-facial reanimation surgeries.
Function and Form Outcomes in Patients with Facial Paralysis 4/1/2016-3/31/2018
R21 DE025295-01A1 Hadlock (Co-PI)
NIDCR 1
This project aims to develop a set of clinically useful measurements of the paralyzed face using three dimensional imaging technology
Multidisciplinary Laser and Reconstructive Facial Surgery Research 07/1/2013-06/30/2018
Lynch Foundation Hadlock/Tan (PI)
The scientific goals are to identify molecular markers for a range of vascular anomalies and hemangiomata, to further clinical outcomes studies in facial paralysis and vascular anomalies, and to develop global outreach and training initiatives involving the treatment of facial disfigurement.
2018-2019
Optogenetic Stimulation of the Facial Nerve
AAFPRS Leslie Bernstein Resident Research Grant
Key Personnel – Mentor (PI: Kanumuri)
To characterize whether viral optogene transfection of the facial nerve would allow for optogentic stimulation as a means to achieve functional stimulation of facial movements.
2018-2019
Enhancement of Axonal Penetration through Cross-Facial Nerve Grafts
AAFPRS Leslie Bernstein Resident Research Grant
Key Personnel – Mentor (PI: Mohan)
To study the effects of various surgical strategies on improving axonal regeneration along cross-facial nerve grafts.
2019-2020
Neuronal and Schwann Cell Transcriptional States in Peripheral Nerve Regeneration
Plastic Surgery Foundation / American Society for Peripheral Nerve Combined Pilot Research Grant
Faculty Mentor (PI: Mohan)
To characterize the heterogeneity of Schwann cell transcriptional states during prolonged peripheral nerve denervation and reinnervation.
R01 NS071067-06A1 Hadlock (PI)
NIH/NINDS 07/01/2010-06/30/2021
Surgical and Rehabilitative Management of Facial Nerve Injury
The scientific goals are through using a rodent model, we propose to employ computer-assisted, patient-specific sensory and motor rehabilitative therapy following facial nerve injury and repair, to measure its benefit and maximize its effect.
2019-2020
Quantitative Model of Decompression Surgery for Bell’s Palsy
AAO-HNSF Resident Research Award
Faculty Mentor (PI: Malka)
To establish the impact of facial nerve decompression following various periods of neural compression on long-term facial function outcomes in a rodent model.
2019-2020
The Effect of Electrical Stimulation on Schwann Cell States Along Nerve Grafts
Leslie Bernstein Resident Research Grant
Sponsor / Faculty Mentor (PI: Derakshan)
To establish the impact of prolonged electrical stimulation of nerve grafts on Schwann cell phenotypes and neural regeneration.
